Renosev 800mg 10pcs Tablet

Uses of Renosev 800

Treatment of Hyperphosphatemia

How does Renosev 800 work?

Renosev 800 is a chelating agent that helps in reducing the phosphorus levels in the blood by binding to the phosphate that enters the body with food and managing its absorption.

Side Effects of Renosev 800

• Headache
• Diarrhea
• Stomach upset
• Constipation

Quick Suggestions:

• Sevelamer is used to control blood phosphate levels in patients who are on dialysis treatment.
• You must take it with food and stick to the diet prescribed by your doctor.
• You may develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Your doctor may prescribe supplements, if necessary.
• Avoid taking any other medicine 1 hour before or 3 hours after taking Sevelamer.
• Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.

Indication:

Sevelamer is used in the treatment of High phosphate levels in blood. It is used in patients with kidney problems and on dialysis.

Pharmacology

Sevelamer carbonate is a non-absorbed phosphate-binding polymer free of metals and calcium. It binds phosphate in the gastrointestinal tract through ionic and hydrogen bonding, reducing phosphate absorption and lowering serum phosphorus levels.

Dosage & Administration

• Starting Dose:
  • 2.4 g (Three 800 mg tablets or sachets) or 4.8 g (Six 800 mg tablets or sachets) daily, taken three times a day with meals.
• Titration and Maintenance:
  • Adjust dose based on serum phosphorus levels every 2-4 weeks until target levels are achieved. The average daily dose is about 6 g.
• For patients switching from other phosphate binders:
  • Adjust the dose on a gram-for-gram basis and monitor serum phosphorus.

Swallow intact; do not crush, chew, or break.

• Pediatric: Not recommended for children under 18 years. Limited effectiveness was noted in children <13 years and those not on dialysis.
• Geriatric: Insufficient data for patients aged 65 and over; no significant differences noted, but cautious dosing is recommended.

Interaction

• Ciprofloxacin: Avoid simultaneous use; can decrease ciprofloxacin's bioavailability by about 50%.
• Other Drugs: May affect absorption of ciclosporin, mycophenolate mofetil, tacrolimus, and levothyroxine. Monitor levels closely if used together.
• Anti-Arrhythmic and Anti-Seizure Medications: Exercise caution; these were not studied in clinical trials.
• General: Administer other medications at least 1 hour before or 3 hours after Sevel to avoid reduced bioavailability.

Contraindications

• Bowel obstruction.
• Hypersensitivity to Sevelamer carbonate, Sevelamer hydrochloride, or any excipients

Pregnancy & Lactation

• Pregnancy: Not systemically absorbed; however, it may decrease serum levels of fat-soluble vitamins and folic acid.
• Lactation: Not expected to be absorbed by the child; may also decrease serum levels of fat-soluble vitamins and folic acid.

Precautions & Warnings

Renosev 800 is not recommended for use if you:

• Have reduced levels of phosphorus in the blood
• Have bowel obstruction

Storage:

Store in a cool, dry place, protected from light.