Renosev 800mg 10pcs Tablet

✔️ Uses of Renosev 800

Treatment of Hyperphosphatemia

✔️ How does Renosev 800 work?

Renosev 800 is a chelating agent that helps in reducing the phosphorus levels in the blood by binding to the phosphate that enters the body with food and managing its absorption.

✔️ Side Effects of Renosev 800

• Headache
• Diarrhea
• Stomach upset
• Constipation

✔️ Quick Suggestions:

• Sevelamer is used to control blood phosphate levels in patients who are on dialysis treatment.
• You must take it with food and stick to the diet prescribed by your doctor.
• You may develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Your doctor may prescribe supplements, if necessary.
• Avoid taking any other medicine 1 hour before or 3 hours after taking Sevelamer.
• Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.

✔️ Indication:

Sevelamer is used in the treatment of High phosphate levels in blood. It is used in patients with kidney problems and on dialysis.

✔️ Pharmacology

Sevelamer carbonate is a non-absorbed phosphate-binding polymer free of metals and calcium. It binds phosphate in the gastrointestinal tract through ionic and hydrogen bonding, reducing phosphate absorption and lowering serum phosphorus levels.

✔️ Dosage & Administration

• Starting Dose:
  • 2.4 g (Three 800 mg tablets or sachets) or 4.8 g (Six 800 mg tablets or sachets) daily, taken three times a day with meals.
• Titration and Maintenance:
  • Adjust dose based on serum phosphorus levels every 2-4 weeks until target levels are achieved. The average daily dose is about 6 g.
• For patients switching from other phosphate binders:
  • Adjust the dose on a gram-for-gram basis and monitor serum phosphorus.

Swallow intact; do not crush, chew, or break.

• Pediatric: Not recommended for children under 18 years. Limited effectiveness was noted in children <13 years and those not on dialysis.
• Geriatric: Insufficient data for patients aged 65 and over; no significant differences noted, but cautious dosing is recommended.

✔️ Interaction

• Ciprofloxacin: Avoid simultaneous use; can decrease ciprofloxacin's bioavailability by about 50%.
• Other Drugs: May affect absorption of ciclosporin, mycophenolate mofetil, tacrolimus, and levothyroxine. Monitor levels closely if used together.
• Anti-Arrhythmic and Anti-Seizure Medications: Exercise caution; these were not studied in clinical trials.
• General: Administer other medications at least 1 hour before or 3 hours after Sevel to avoid reduced bioavailability.

✔️ Contraindications

• Bowel obstruction.
• Hypersensitivity to Sevelamer carbonate, Sevelamer hydrochloride, or any excipients

✔️ Pregnancy & Lactation

• Pregnancy: Not systemically absorbed; however, it may decrease serum levels of fat-soluble vitamins and folic acid.
• Lactation: Not expected to be absorbed by the child; may also decrease serum levels of fat-soluble vitamins and folic acid.

✔️ Precautions & Warnings

Renosev 800 is not recommended for use if you:

• Have reduced levels of phosphorus in the blood
• Have bowel obstruction

✔️ Storage:

Store in a cool, dry place, protected from light.