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Renosev 800mg 10pcs Tablet
- Used to control the serum phosphorous levels in patients with chronic kidney disease who are on dialysis
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✅ Description:
Hyperphosphatemia
Hyperphosphatemia is characterized by elevated levels of phosphate in the blood. This condition frequently arises as a complication of chronic kidney disease (CKD).
Role of Phosphate:
- Phosphate is an essential electrolyte that helps:
- Strengthen bones and teeth.
- Produce energy.
Causes:
- In chronic kidney disease, the kidneys are unable to effectively remove excess phosphate from the body, leading to elevated blood phosphate levels.
Complications:
- Muscle Problems: Elevated phosphate levels can contribute to muscle discomfort or issues.
- Bone Health: Increased phosphate levels can weaken bones, leading to conditions such as renal bone disease.
- Cardiovascular Risks: Higher phosphate levels are associated with an increased risk of heart attacks and strokes.
Symptoms:
- Itchy skin.
- Red eyes.
- Bone pain.
- Fractures.
Prevalence:
- Hyperphosphatemia is more common in individuals with chronic kidney disease and those undergoing dialysis.
Safety Advices
Alcohol
UNSAFE
You are recommended to avoid alcohol consumption while taking Renosev 800 to avoid unpleasant side effects.
Pregnancy
CONSULT YOUR DOCTOR
Renosev 800 is a Category C pregnancy medicine. Please consult your doctor if you have any concerns; your doctor will prescribe you Renosev 800 only if the benefits outweigh the risks.
Breastfeeding
CONSULT YOUR DOCTOR
The safety of Renosev 800 has not been established in breastfeeding women. Please consult your doctor if you have any concerns regarding this; your doctor will decide whether the Renosev 800 can be given to breastfeeding mothers or not.
Driving
CAUTION
Renosev 800 has no or negligible influence on the ability to drive or operate any machinery.
Kidney
CONSULT YOUR DOCTOR
Dose adjustment may be needed. Renosev 800 should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Liver
CONSULT YOUR DOCTOR
Renosev 800 should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.
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✔️ Uses of Renosev 800
Treatment of Hyperphosphatemia
✔️ How does Renosev 800 work?
Renosev 800 is a chelating agent that helps in reducing the phosphorus levels in the blood by binding to the phosphate that enters the body with food and managing its absorption.
✔️ Side Effects of Renosev 800
- Headache
- Diarrhea
- Stomach upset
- Constipation
✔️ Quick Suggestions:
- Sevelamer is used to control blood phosphate levels in patients who are on dialysis treatment.
- You must take it with food and stick to the diet prescribed by your doctor.
- You may develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Your doctor may prescribe supplements, if necessary.
- Avoid taking any other medicine 1 hour before or 3 hours after taking Sevelamer.
- Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.
✔️ Indication:
Sevelamer is used in the treatment of High phosphate levels in blood. It is used in patients with kidney problems and on dialysis.
✔️ Pharmacology
Sevelamer carbonate is a non-absorbed phosphate-binding polymer free of metals and calcium. It binds phosphate in the gastrointestinal tract through ionic and hydrogen bonding, reducing phosphate absorption and lowering serum phosphorus levels.
✔️ Dosage & Administration
- Starting Dose:
- 2.4 g (Three 800 mg tablets or sachets) or 4.8 g (Six 800 mg tablets or sachets) daily, taken three times a day with meals.
- Titration and Maintenance:
- Adjust dose based on serum phosphorus levels every 2-4 weeks until target levels are achieved. The average daily dose is about 6 g.
- For patients switching from other phosphate binders:
- Adjust the dose on a gram-for-gram basis and monitor serum phosphorus.
Swallow intact; do not crush, chew, or break.
- Pediatric: Not recommended for children under 18 years. Limited effectiveness was noted in children <13 years and those not on dialysis.
- Geriatric: Insufficient data for patients aged 65 and over; no significant differences noted, but cautious dosing is recommended.
✔️ Interaction
- Ciprofloxacin: Avoid simultaneous use; can decrease ciprofloxacin's bioavailability by about 50%.
- Other Drugs: May affect absorption of ciclosporin, mycophenolate mofetil, tacrolimus, and levothyroxine. Monitor levels closely if used together.
- Anti-Arrhythmic and Anti-Seizure Medications: Exercise caution; these were not studied in clinical trials.
- General: Administer other medications at least 1 hour before or 3 hours after Sevel to avoid reduced bioavailability.
✔️ Contraindications
- Bowel obstruction.
- Hypersensitivity to Sevelamer carbonate, Sevelamer hydrochloride, or any excipients
✔️ Pregnancy & Lactation
- Pregnancy: Not systemically absorbed; however, it may decrease serum levels of fat-soluble vitamins and folic acid.
- Lactation: Not expected to be absorbed by the child; may also decrease serum levels of fat-soluble vitamins and folic acid.
✔️ Precautions & Warnings
Renosev 800 is not recommended for use if you:
- Have reduced levels of phosphorus in the blood
- Have bowel obstruction
✔️ Storage:
Store in a cool, dry place, protected from light.
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